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The effects of overdose of dexlansoprazole in humans are not known (although the acute toxicity is likely to be low) and, consequently, instruction for treatment cannot be given.
There have been no reports of significant overdose of Dexilant. Multiple doses of Dexilant 120 mg and a single dose of Dexilant 300 mg did not result in death or other severe adverse events. Serious adverse reactions of hypertension have been reported in association with twice daily doses of Dexilant 60 mg. Non serious adverse reactions observed with twice daily doses of Dexilant 60 mg include hot flushes, contusion, oropharyngeal pain, and weight loss.
In the case of suspected overdose the patient should be monitored. Dexlansoprazole is not significantly eliminated by haemodialysis. If necessary, gastric emptying, charcoal and symptomatic therapy is recommended.
