Discontinue use if subacute cutaneous lupus erythematosus occurs; at 1st signs or symptoms of severe cutaneous ARs or other signs of hypersensitivity. Gastric malignancy. Increased risk of
Clostridium difficile-associated diarrhea; osteoporosis-related hip, wrist or spine fractures. Hypomagnesemia, hypomagnesemia-associated hypocalcemia &/or hypokalemia. Vit B
12 malabsorption due to hypo- or achlorhydria. Ensure adequate intake of vit D & Ca. Long-term & high-dose use. Discontinue use at least 5 days prior to chromogranin A measurements. Concomitant use w/ digoxin or drugs causing hypomagnesemia eg, diuretics; high-dose MTX. Severe hepatic impairment. Pregnancy & lactation. Childn <12 yr.
Sign Out
