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Pharmacology: Cloxacilla, a semi-synthetic penicillin, is Penicillinase stable and active against Gram-positive organisms particularly penicillinase producing Staphylococci, Streptococci and Pneumococci.
Pharmacokinetics: Cloxacilla, is well absorbed: administration of higher doses result in a proportionately higher increase in serum levels. Concurrent administration of Probenecid to patient with normal renal functions causes a higher and prolonged serum level. Cloxacillin is excreted by glomerular filtration and renal tubular secretion.
