Cipram Drug Interactions

Simultaneous administration of citalopram and MAOIs may cause serotonin syndrome. A pharmacokinetic interaction study of citalopram and metoprolol has shown a 2-fold increase in metoprolol concentrations. There was no statistically significant increase in the effect of metoprolol on blood pressure and heart rate in healthy volunteers by adding citalopram. Cimetidine cause a moderate increase in the average steady-state level of citalopram. Caution should be exercised at the upper end of the dose range of citalopram when it is used concomitantly with high doses of cimetidine. There is no interaction with lithium and alcohol, and no clinically important interactions with levomepromazine and imipramine. Studies have shown that citalopram is unlikely to have any effect on the pharmacokinetics of carbamazepine and its metabolite carbamazepine-epoxide. Citalopram does not cause any changes in the pharmacokinetics of digoxin. No pharmacodynamic interactions have been found in clinical studies in which citalopram has been given concomitantly with benzodiazepines, neuroleptics, analgesics, antihistamines, antihypertensive drugs, β-blockers and other cardiovascular drugs.
Incompatibilities: Not applicable.