Cholib Dosage/Direction for Use

Secondary causes of hyperlipidaemia, such as uncontrolled type 2 diabetes mellitus, hypothyroidism, nephrotic syndrome, dysproteinemia, obstructive liver disease, pharmacological treatment (like oral oestrogens), alcoholism should be adequately treated, before Cholib 145 mg/20 mg film-coated tablet therapy is considered and patients should be placed on a standard cholesterol and triglycerides lowering diet which should be continued during treatment.
Posology: The recommended dose is one tablet per day. Grapefruit juice should be avoided (see Interactions).
Response to therapy should be monitored by determination of serum lipid values (total cholesterol (TC), LDL-C, triglycerides (TG)).
Elderly patients (≥ 65 years old): No dose adjustment is necessary. The usual dose is recommended, except for decreased renal function with estimated glomerular filtration rate < 60 mL/min/1.73 m² where Cholib 145 mg/20 mg film-coated tablet is contraindicated (see Contraindications).
Patients with renal impairment: Cholib 145 mg/20 mg film-coated tablet is contraindicated in patients with moderate to severe renal insufficiency whose estimated glomerular filtration rate is < 60 mL/min/1.73 m² (see Contraindications). Cholib 145 mg/20 mg film-coated tablet should be used with caution in patients with mild renal insufficiency whose estimated glomerular filtration rate is 60 to 89 mL/min/1.73 m² (see Precautions).
Patients with hepatic impairment: Cholib 145 mg/20 mg film-coated tablet has not been studied in patients with hepatic impairment and is therefore contraindicated in this population (see Contraindications).
Paediatric population: Cholib 145 mg/20 mg film-coated tablet is contraindicated in children and adolescents up to 18 years old (see Contraindications).
Method of administration: Each tablet should be swallowed whole with a glass of water. The tablets should not be crushed or chewed. They may be taken with or without food (see Pharmacology: Pharmacokinetics under Actions).