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No impairment of renal function has been observed after concurrent administration of large doses of ceftriaxone and loop diuretic (eg. furosemide). There is no evidence that ceftriaxone increases renal toxicity of aminoglycosides. No effects similar to that of disulfiram has been demonstrated after ingestion of alcohol subsequent to the administration of ceftriaxone.
The elimination of ceftriaxone is not altered by probenecid.
In an in vitro study, antagonistic effects have been observed with the combination of chloramphenicol and ceftriaxone.
Influence on Diagnostic Tests: In patients treated with CEFTREX, the Coombs' test may rarely become false-positive. CEFTREX, like other antibiotics, may result in false-positive tests for galactosemia. Likewise, non-enzymatic methods for the glucose determination in urine may give false-positive results. For this reason, urine-glucose determination during therapy with CEFTREX should be done enzymatically.
