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Hematological changes: Eosinophilia, leukopenia, granulocytopenia, hemolytic anemia, thrombocytopenia.
Skin reaction: Exanthema, allergic dermatitis, pruritus, urticaria, edema. Isolated cases of severe cutaneous adverse reactions (erythema multiforme, Stevens-Johnson syndrome or Lyell's syndrome/toxic epidermal necrolysis) have been reported.
Other rare adverse effects: Headache and dizziness, increase in liver enzymes, gallbladder sludge, oliguria, increase in serum creatinine, mycosis of the genital tract, shivering and anaphylactoid reactions.
Local adverse effects: In rare cases, phlebitic reaction occurred after IV administration.
These may be prevented by slow injection (2-4 minutes).
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