Use in pregnancy: Animal studies have shown that aspirin can cause birth defects in numerous species. There is no conclusive evidence that aspirin causes malformation in humans. Drugs, eg aspirin inhibit prostaglandin synthesis. When given late in pregnancy, it may cause premature closure of the fetal ductus arteriosus, prolong labour and delay birth. Aspirin increases the bleeding time both in the newborn infant and in the mother because of its antiplatelet effects. Products containing aspirin should be avoided in late pregnancy.
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