Casprin Special Precautions

Because of its relatively low dosage and enteric-coating dosage form, the risk of Casprin in causing gastrointestinal ulceration is greatly reduced. However, care should be taken in administering Casprin to patients with prior history of serious gastrointestinal events.
Concurrent use of Casprin with alcoholic beverages should be avoided in order to avoid gastrointestinal toxicity.
Care should be taken when aspirin us administered to asthmatic patients.
Caution is necessary when renal or hepatic function is impaired.
Use in pregnancy: Animal studies have shown that aspirin can cause birth defects in numerous species. There is no conclusive evidence that aspirin causes malformation in humans. Drugs, eg aspirin inhibit prostaglandin synthesis. When given late in pregnancy, it may cause premature closure of the fetal ductus arteriosus, prolong labour and delay birth. Aspirin increases the bleeding time both in the newborn infant and in the mother because of its antiplatelet effects. Products containing aspirin should be avoided in late pregnancy.
Use in children: The use of aspirin in children <16 years is not recommended because of the risk of Reye's syndrome.