Symptoms and Treatment of Overdose(s): Symptoms of more severe intoxication or of acute poisoning following overdosage include hyperventilation, fever, restlessness, ketosis and respiratory alkalosis and metabolic acidosis. In acute salicylate overdosage by mouth, the stomach should be emptied by lavage. Salicylate remaining in the stomach may be adsorbed by activated charcoal. Fluid and electrolyte management is the mainstay of treatment with the immediate aim being correction of acidosis, hyperpyrexia, hypokalaemia and dehydration. Alkaline diuresis, haemodialysis or haemoperfusion are effective methods of removing salicylate from the plasma.
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