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There has been little use of fluconazole during pregnancy in humans. Adverse fetal effects have been seen in animals only at high-dose levels associated with maternal toxicity. These findings are not considered relevant to fluconazole used at therapeutic doses. However, use in pregnancy should be avoided except in patients with severe or potentially life-threatening fungal infections in whom fluconazole may be used if the anticipated benefit outweighs the possible risk to the fetus.
Fluconazole is found in human breast milk at concentrations similar to plasma, hence, its use in nursing mothers is not recommended.
