Cryptococcal meningitis & cryptococcal infections at other sites Adult 400 mg on 1st day followed by 200-400 mg once daily. Duration of treatment for cryptococcal meningitis: 6-8 wk.
Childn 6-12 mg/kg daily.
Prevention of relapse of cryptococcal meningitis in patient w/ AIDS, after receiving full course of primary therapy Daily dose: 200 mg.
Candidemia, disseminated candidiasis & other invasive candidal infections 400 mg on 1st day followed by 200 mg daily, may be increased to 400 mg daily.
Oropharyngeal candidiasis 50 mg once daily for 7-14 days or longer in patient w/ severely compromised immune function.
Childn 3 mg/kg daily. Loading dose: 6 mg/kg may be used on 1st day.
Atropic oral candidiasis associated w/ dentures 50-100 mg once daily for 7-14 days concurrently w/ local antiseptic measures to the denture.
Other candidal infections of mucosa (except vag candidiasis) 50 mg daily for 14-30 days.
Unusually difficult case of mucosal candidal infection May be increased up to 100 mg daily.
Vag candidiasis 150 mg as single daily dose.
Prevention of candidiasis 50-400 mg once daily.
Dermal infections including tinea pedis, tinea corporis, tinea cruris & candida infections 150 mg once wkly or 50 mg once daily for 2-4 wk.
Tinea pedis Up to 6 wk.
Tinea versicolor 50 mg once daily for 2-4 wk.
Infant 0-1 wk Same dose as older childn every 72 hr,
2-4 wk Same dose as older childn every 48 hr.
Renal impairment Loading dose: 50-400 mg.
CrCl >50 100% of recommended dose,
CrCl 11-50 50% of recommended dose,
patient on dialysis 1 dose after every dialysis.
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