Benzylpenicillin is indicated for most wound infections, pyogenic infections of the skin, soft tissue infections and infections of the respiratory tract.
It is also indicated for the following infections caused by penicillin-sensitive microorganisms: Generalised infections and septicaemia from susceptible bacteria.
Acute and chronic osteomyelitis, sub-acute bacterial endocarditis and meningitis caused by susceptible organisms.
Tetanus, actinomycosis, anthrax, rat-bite fever, listeriosis and severe Lyme disease.
Complications secondary to gonorrhoea and syphilis (e.g. gonococcal arthritis or endocarditis, congenital syphilis and neurosyphilis).
Diphtheria, brain abscesses and pasteurellosis.
Consideration should be given to official local guidance (e.g. national recommendations) on the appropriate use of antibacterial agents.
Susceptibility of the causative organism to the treatment should be tested (if possible), although therapy may be initiated before the results are available.