Adult 600-3,600 mg daily in 4-6 divided doses, depending on indication.
Meningitis Up to 14.4 g IV daily in divided doses.
Bacterial endocarditis 7.2-12 g IV daily in divided doses.
Childn 1 mth-12 yr 100 mg/kg daily in 4 divided doses. Max: 4 g daily.
Infant 1-4 wk 75 mg/kg daily in 3 divided doses.
Newborn 50 mg/kg daily in 2 divided doses.
Meningococcal disease Adult & childn >12 yr 2.4 g every 4 hr.
Childn 1 mth-12 yr 180-300 mg/kg daily in 4-6 divided doses. Max: 12 g daily.
Infant 1-4 wk 150 mg/kg daily in 3 divided doses.
Newborn 100 mg/kg daily in 2 divided doses.
Premature & neonate Not more frequent than every 8-12 hr.
Renal insufficiency 0.6-1.2 g no more frequent than every 8-10 hr.
Advanced liver disease associated w/ severe renal failure Reduce to 300 mg every 8 hr.
Haemodialysis Additional 300 mg every 6 hr during procedure.
Sign Out
