Hypersensitivity reactions: Allergic reactions are uncommon. Potential allergic reactions include urticaria, angioneurotic edema, erythema multiforme, exfoliative dermatitis, fever, joint pain or anaphylactic shock with a collapse and anaphylactoid reactions (asthma, purpura, gastrointestinal symptoms).
Gastro-intestinal side effects: Stomatitis and glossitis are, at times, seen. In patients developing diarrhea during treatment pseudomembranous colitis should be thought of.
Hematological side effects: Positivity of the direct Coombs' test, hemolytic anemia, leucopenia, thrombocytopenia and agranulocytosis have been reported, but are extremely rare.
Other side effects: Neuropathy, nephropathy.
Patients treated for syphilis may develop Jarisch-Herxheimer reactions secondary to bacteriolysis.
Infants may show local reactions.
Although extremely rare, accumulation of PVP in the reticuloendothelial system (RES) or local PVP accumulation and foreign body granulomas mimicking tumors cannot altogether be excluded.