benzathine benzylpenicillin




Averroes Pharma
Concise Prescribing Info
Penicillin G benzathine
Acute tonsillitis, chronic erysipela, erysipeloid, wound infections, bite wounds, other treponemal infections (yaws, bejel, pinta). Prevention of rheumatic fever (chorea, rheumatic heart disease), poststreptococcal glomerulonephritis, erysipela. Treatment & prevention of scarlet fever, syphilis.
Dosage/Direction for Use
Congenital syphilis in neonate or infant w/o neurological involvelment 1,200,000 u. Primary syphillis 1 dose, secondary syphilis 2 doses, late (tertiary, seropositive) syphilis 1-2 doses wkly for 3-5 wk. Yaws Adult 1,200,000-2,400,000 u. Childn <12 yr 600,000 u. Pinta Adult 2,400,000 u. Childn 1,200,000 u. Other infections Adult 1,200,000 or 2,400,000 u once wkly. Childn <12 yr 600,000 u at 1-3 day intervals. Alternatively 1,200,000 u at 2-4 wk intervals. Prevention of recurrent rheumatic fever, rheumatic endocarditis, chorea, poststreptococcal glomerulonephritis, erysipela Adult 1,200,000-2,400,000 u at 4-wk intervals. Childn <12 yr 600,000 u at 14-day intervals or 1,200,000 u at 4-wk intervals. Prevention of scarlet fever in contacts Adult 2,400,000 u. Childn <12 yr 600,000 u or alternatively 1,200,000 u at wkly intervals.
Hypersensitivity to penicillins or cephalosporins. Allergic diathesis or bronchial asthma.
Special Precautions
Discontinue use if allergic reactions occur. Not to be inj SC, IV, intrathecally or instilled into body cavities. Avoid inadvertent intravascular & intra-arterial inj. Allergic diathesis; bronchial asthma; diabetics; antibiotic-related pseudomembranous colitis. Potential overgrowth of resistant organisms; monitor blood count & renal function during long-term therapy. Perform dark-field exam prior to therapy & obtain serologic tests for at least 4 mth in patients treated for venereal diseases suspected w/ co-existent syphilis. Pregnancy & lactation. Not to be inj into upper outer quadrant of buttock in infants & small childn.
Adverse Reactions
Urticaria, angioneurotic edema, erythema multiforme, exfoliative dermatitis, fever, joint pain, anaphylactic shock w/ collapse, anaphylactoid reactions; stomatitis, glossitis, diarrhea, pseudomembranous colitis; neuropathy, nephropathy. Jarisch-Herxheimer reactions secondary to bacteriolysis, local reactions in infant.
Drug Interactions
Substantial mutual inactivation w/ extemporaneous admixtures of β-lactams & aminoglycosides. Reduced aminoglycosides serum conc. Competitive drug elimination inhibition w/ anti-inflammatories, antirheumatics, antipyretics (eg, indomethacin, phenylbutazone, high-dose salicylates), probenecid. Reduced efficacy of OCs. Not to be combined w/ bacteriostatic antibiotics. Avoid administration w/ mixed-content syringes.
MIMS Class
ATC Classification
J01CE08 - benzathine benzylpenicillin ; Belongs to the class of beta-lactamase sensitive penicillins. Used in the systemic treatment of infections.
Benzapen powd for inj 2.4 Million unit
10 × 1's;50 × 1's
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in