Benzapen Dosage/Direction for Use

Sterile Penicillin G Benzathine is administered by intramuscular injection.
Treatment of syphilis: 1) Congenital syphilis in neonates or infants (without neurological involvement): 1, 200 000 units injected at 2 sites.
2) Primary, secondary, latent syphilis: a) Primary: I dose of 2, 400 000 units injected at 2 sites.
b) Secondary: 2 doses of Sterile pencillin G benzathine 2.4 MU Injected at 2 sites. Repeat treatment if clinical symptoms recur or if laboratory tests are persistently positive.
c) Late (tertiary, seropositive): 1-2 doses of Sterile pencillin G benzathine 2.4 MU weekly for 3 to 5 weeks.
Treatment of yaws: Children under 12 years: 600 000 units.
Adults: 1, 200 000 units to 2, 400 000 units.
Contacts and persons with latent infections are given half of these doses.
Treatment of pinta: Children: 1, 200 000 units.
Adults: 2, 400 000 units.
Other infections: Children under 12 years: 600 000 units at intervals of 3 days or daily, depending on the severity of the disease. Alternatively, 1, 200 000 units at intervals of 2 to 4 weeks.
Adults: 1, 200 000 units or 2, 400 000 units once a week.
Prophylaxis: Prevention of recurrent rheumatic fever, rheumatic endocarditis, chorea, poststreptococcal glomerulonephritis and erysipela: Children under 12 years: 600 000 units at intervals of 14 days or 1, 200 000 units at intervals of 4 weeks.
Adults: 1, 200 000 units to 2, 400 000 units at intervals of 4 weeks.
Prevention of scarlet fever in contacts: Children under 12 years: 600 000 units or, alternatively, 1, 200 000 units at weekly intervals.
Adults: 2, 400 000 units.
To prevent complications, patients with streptococcal disease should receive treatment for at least 10 days.
This can generally be ensured with a single injection of 600 000 units in children under age 12 years, with a single injection of 1, 200 000 units in children over age 12 years and with a single injection of 2, 400 000 units in adults.
Do not apply more than 50 mg of PVP (equivalent to 2, 400 000 units) at one injection site. Inject higher single doses (e. g. 2 doses of 2, 400 000 units) at 2 different sites.
How to use: Dissolve the contents in 8ml or more of Sterilized Water for Injections immediately before use.