Azytro Drug Interactions

Antacids: In patients receiving azithromycin and antacids, azithromycin should be taken at least 1 hour before or 2 hours after the antacid.
Cyclosporin: Caution should be exercised before considering coadministration of azithromycin and cyclosporin. If coadministration is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Digoxin: Some of the macrolide antibiotics have been reported to impair the metabolism of digoxin in the gut) in some patients. Therefore, in patients receiving concomitant azithromycin and digoxin the possibility of raised digoxin levels shoud be borne in mind, and digoxin levels monitored.
Ergot derivatives: Because of the theoretical possibility of ergotism, azithromycin and ergot derivatives should not be coadministered.
Terfenadine: As with other macrolides, azithromycin should be administered with caution in combination with terfenadine.
Theophylline: Theophylline levels may be increased in patients taking azithromycin.
Coumarin-Type Oral Anticoagulants: Consideration should be given to the frequency of monitoring prothrombin time when azithromycin is used in patients receiving coumarin-type oral anticoagulants.
Zidovudine: To be used with caution as administration of azithromycin increased the concentrations of phosphorylated zidovudine, the clinically active metabolite, in peripheral blood mononuclear cells. The clinical significance of this finding is unclear, but it may be of benefit to patients.