Sign Out
To be administered orally.
Azytro should be given as a single daily dose. The period of dosing with regard to infection is given below.
Azytro can be taken with food.
In adults: For the treatment of sexually transmitted diseases caused by Chlamydia trachomatis, or susceptible Neisseria gonorrhea, the dose is 1000 mg as a single oral dose.
For prophylaxis against MAC infections in patients infected with the human immunodeficiency virus (HIV), the dose is 1200 mg once per week.
According to the 1999 USPHS/IDSA Guidelines for the Prevention of Opportunistic infections in Persons infected with Human Immunodeficiency Virus, the optimal criteria for discontinuing MAC prophylaxis remain to be defined. However, a reasonable option would be to consider discontinuing prophylaxis in patients with a CD4+ T-lymphocyte count greater than 100 cells/microlitre for a sustained period (eg. greater than 3-6 months.)
For all other indications, the total dosage of 1500 mg should be given as 500 mg daily for 3 days. As an alternative, the same total dose can be given over 5 days with 500 mg given on day 1, then 250 mg daily on days 2 to 5.
In the elderly: The same dose range as in younger patients may be used in elderly.
In patients with renal impairment: No dose adjustment is necessary in patients with mild to moderate (GFR 10 - 80 ml/min) or severe (GFR < 10 ml/min) renal impairment (see Precautions).
In patients with hepatic impairment: See Precautions.
In children: With the single exception of the treatment of streptococcal pharyngitis, the total dose in children is 30 mg/kg which should be given as a single daily dose of 10 mg/kg daily for 3 days or as an alternative, given 5 days with a single daily dose of 10 mg/kg on day 1, then 5 mg/kg on days 2 -5.
Treatment of acute otitis media in children may be given as either a single dose of 30 mg/kg or as 10 mg/kg daily for 3 days.
Azytro Tablet should only be administered to children weighing more than 45 kg.
Safety and efficacy for the prevention of MAC in children have not been established. Based on pediatric pharmaceutic data, a dose of 20 mg/kg would be similar to the adult dose of 1200 mg but with higher Cmax.
For pediatric streptococcal pharyngitis, azithromycin given as a single dose of 10 mg/kg or 20 mg/kg for 3 days has been shown to be effective; however, do not exceed a daily dose of 500 mg. In clinical trials comparing these two dosage regimens, similar clinical efficacy was observed but greater bacteriologic eradication was evident at the 20 mg/kg/day dose. However, penicillin is the usual drug of choice in the treatment of Streptococcus pyogenes pharyngitis, including prophylaxis of rheumatic fever.
