Adult & elderlySTD caused by C trachomatis or susceptible N gonorrhoea 1,000 mg as single dose. Prophylaxis against MAC infections 1,200 mg once wkly. All other indications 1,500 mg given as 500 mg daily for 3 days or for 5 days given as 500 mg on day 1, then 250 mg daily on days 2-5. Childn >45 kg Total dose: 30 mg/kg given as single daily dose of 10 mg/kg daily for 3 days or for 5 days given as 10 mg/kg on day 1, then 5 mg/kg on days 2-5. Acute otitis media 30 mg/kg as single dose or 10 mg/kg daily for 3 days. PedStrep pharyngitis 10 or 20 mg/kg as single dose for 3 days. Max: Not to exceed 500 mg daily.
Discontinue use if severe acute hypersensitivity reactions occur. Congenital or documented QT prolongation; electrolyte disturbance, clinically relevant bradycardia, cardiac arrhythmia or insufficiency. Superinfection. lnfantile hypertrophic pyloric stenosis. Concomitant use w/ drugs prolonging QT interval eg, class IA & III antiarrhythmics, antipsychotics, antidepressants, fluoroquinolones. Severe renal impairment. Not to be used in hepatic impairment. Pregnancy & lactation. Elderly.
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