Avoral Mechanism of Action

Pharmacology: Pharmacodynamics: Sodium Bicarbonate acts as alkalinizing agent which increases the excretion of free bicarbonate ions in the urine, and thus raises the urinary pH. A rise in urinary pH increases the solubility of cysteine in the urine. By maintaining alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium Bicarbonates acts as antacid as well by neutralizing or buffering existing quantities of stomach acid but has no direct effect in its output.
Sodium Citrate is metabolized to bicarbonates after absorption, thus providing similar pharmacological effect as per Sodium Bicarbonate.
Citric Acid and Tartaric Acid both having transient effect as neutralizing or buffering agents.
Pharmacokinetics: After absorption, Sodium Citrate is metabolized to bicarbonates. Sodium Bicarbonate is excreted through kidney and also via lung by forming carbon dioxide. Sodium Citrate, Citric Acid and Tartaric Acid are excreted through urine. Less than 5% of the citrates are excreted in the urine unchanged.