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Use of urinary alkalizer theoretically may result in decreased therapeutic effect of chlorpropamide, lithium, salicylates and tetracyclines; increased therapeutic effect of amphetamines, ephedrine and pseudoephedrine.
Antacid: Concurrent use of antacids with Sodium Citrate and Sodium Bicarbonate may promote development of calcium stones in patients with uric acid stones and may also cause hypernatremia. Concurrent use of aluminium containing antacids with salts can increase aluminium absorption, possibly resulting in acute aluminium toxicity, especially in patients with renal insufficiency.
Quinolones: Citrates may reduce the solubility of ciprofloxacin, norfloxacin, or ofloxacin in the urine. Patients should be observed for signs of crystalluria and nephrotoxicity.
