Very common effects (likely to affect more than 1 in 10 people): A gradual change in the eye colour by increasing the amount of brown pigment in the coloured part of the eye known as the iris. If the patient has mixed-colour eyes (blue-brown, grey-brown, yellow-brown or green-brown) the patient is more likely to see this change than if the patient has eyes of one colour (blue, grey, green or brown eyes). Any changes in the eye colour may take years to develop although it is normally seen within 8 months of treatment. The colour change may be permanent and may be more noticeable if the patient use Avetaprost in only one eye. There appears to be no problems associated with the change in eye colour. The eye colour change does not continue after Avetaprost treatment is stopped.
Redness of the eye.
Eye irritation (a feeling of burning, grittiness, itching, stinging or the sensation of a foreign body in the eye).
A gradual change to eyelashes of the treated eye and the fine hairs around the treated eye, seen mostly in people of Japanese origin. These changes involve an increase of the colour (darkening), length, thickness and number of the eye lashes.
Common effects (likely to affect less than 1 in 10 people): Irritation or disruption to the surface of the eye, eyelid inflammation (blepharitis) and eye pain.
Uncommon effects (likely to affect less than 1 in every 100 people): Eyelid swelling, dryness of the eye, inflammation or irritation of the surface of the eye (keratitis), blurred vision and conjunctivitis.
Rare effects (likely to affect less than 1 in every 1000 people): Inflammation of the iris, the coloured part of the eye (iritis/uveitis); swelling of the retina (macular oedema), symptoms of swelling or scratching/damage to the surface of the eye, swelling around the eye (periorbital oedema) misdirected eyelashes or an extra row of eyelashes.
Skin reactions on the eyelids, darkening of the skin of the eyelids.
Asthma, worsening of asthma and shortness of breath (dyspnoea).
Very rare effects (likely to affect less than 1 in 10,000 people): Worsening of angina in patients who also have heart disease. Chest pain.
Patients have also reported the following side-effects: fluid filled area within the coloured-part of the eye (iris cyst), headache, dizziness, palpitations, muscle pain and joint pain.
Side effects seen more often in children compared to adults are: runny itchy nose and fever.
If any of the side effects become serious, or if patient notices any side effects not listed in this leaflet, contact a doctor or pharmacist.