Aubagio Contraindications

Hypersensitivity to the active substance or to any of the excipients.
Patients with severe hepatic impairment (Child-Pugh class C).
Pregnant women, or women of childbearing potential who are not using reliable contraception during treatment with teriflunomide and thereafter as long as its plasma levels are above 0.02 mg/l (see Use in Pregnancy & Lactation). Pregnancy must be excluded before start of treatment (see Use in Pregnancy & Lactation).
Breast-feeding women (see Use in Pregnancy & Lactation).
Patients with severe immunodeficiency states, e.g. AIDS.
Patients with significantly impaired bone marrow function or significant anaemia, leucopenia, neutropenia or thrombocytopenia.
Patients with severe active infection until resolution (see Precautions).
Patients with severe renal impairment undergoing dialysis, because insufficient clinical experience is available in this patient group.
Patients with severe hypoproteinaemia, e.g. in nephrotic syndrome.