View Aubagio overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Swallow whole w/ water.
Contraindications
Hypersensitivity. Severe immunodeficiency states eg, AIDS; significant bone marrow function impairment or anaemia, leucopenia, neutropenia or thrombocytopenia; severe active infection & hypoproteinaemia eg, nephrotic syndrome. Severe renal & hepatic (Child-Pugh class C) impairment. Women of childbearing potential. Pregnancy & lactation.
Discontinue use if liver injury is suspected; new onset or worsening pulmonary symptoms eg, persistent cough & dyspnoea, severe haematological reactions eg, pancytopenia; ulcerative stomatitis, skin &/or mucosal reactions occurs; peripheral neuropathy develops. Not to be used in severe hypoproteinaemia. Active acute or chronic infections, latent TB; history of ILD; new onset or worsening of psoriasis. Delay initiation in patients w/ severe active infection until resolution. Substantial alcohol consumption. Monitor & assess BP, ALT/SGPT & CBC ie, differential WBC & platelet count prior to & during treatment. Assess hepatic enzymes prior to & every 2 wk during 1st 6 mth & every 8 wk thereafter. Determine total albumin adjusted serum Ca conc. Avoid use w/ live attenuated vaccines. Not recommended w/ leflunomide. Concomitant use w/ interferon β or glatiramer acetate. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Preexisting hepatic disease. Women of childbearing potential should use effective contraception during & after treatment. Not to be used during pregnancy & lactation. Childn 10 to <18 yr. Elderly ≥65 yr.
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