The maximum tolerated dose of Adalimumab has not been established in humans. No dose-limiting toxicities have been observed during clinical trials with Adalimumab. Multiple doses up to 10 mg/kg have been administered to patients in clinical trials without evidence of dose-limiting toxicities. In case of overdosage, it is recommended that the patient be monitored for any signs or symptoms of adverse reactions or effects and appropriate symptomatic treatment instituted immediately.