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Effect of Other Drugs on AFINITOR: Inhibitors: Avoid the concomitant use of P-gp and strong CYP3A4 inhibitors [see Dosage & Administration, Pharmacology under Actions].
Reduce the dose for patients taking AFINITOR with a P-gp and moderate CYP3A4 inhibitor as recommended [see Dosage & Administration, Pharmacology under Actions].
Inducers: Increase the dose for patients taking AFINITOR with a P-gp and strong CYP3A4 inducer as recommended [see Dosage & Administration, Pharmacology under Actions].
Effects of Combination Use of Angiotensin Converting Enzyme (ACE) Inhibitors: Patients taking concomitant ACE inhibitors with AFINITOR may be at increased risk for angioedema. Avoid the concomitant use of ACE inhibitors with AFINITOR [see Precautions].
