Zolysan Drug Interactions

The Benzodiazepines, including Alprazolam, produce additive CNS depressant effects when co-administered with other psychotropic medications, anticonvulsants, antihistaminics, ethanol, and other drugs which themselves produce CNS depression.
The co-administration of Alprazolam with Ketoconazole, Itraconazole, or other azole type antifungals is not recommended.
Caution and consideration of dose reduction is recommended when alprazolam is co-administered with Nefazodone, Fluvoxamine, and Cimetidine.
Caution is recommended when Alprazolam is coadministered with Fluoxetine, Propoxyphene, oral contraceptives, Diltiazem, or macrolide antibiotics such as Erythromycin and Troleandomycin.
Interactions involving HIV protease inhibitors (e.g., Ritonavir) and Alprazolam are complex and time dependent.
Increased Digoxin concentrations have been reported when Alprazolam was given, especially in elderly (> 65 years of age). Patients who receive Alprazolam and Digoxin should therefore be monitored for signs and symptoms related to Digoxin toxicity.