Very common: Depression, sedation, somnolence, ataxia, memory impairment, dysarthria, dizziness, headache, constipation, dry mouth, fatigue, and irritability. The most common adverse reactions in patients with panic-related disorders were drowsiness, and slurred speech.
Common: Decreased appetite, confusional state, disorientation, libido decreased, anxiety, insomnia, nervousness, libido increased, balance disorder, coordination abnormal, disturbance in attention, hypersomnia, lethargy, tremor, vision blurred, nausea, dermatitis, sexual dysfunction, weight decreased, and weight increased.
Uncommon: Mania, hallucination, anger, agitation, amnesia, muscular weakness, incontinence, and menstruation irregular.
Frequency not known: Hyperprolactinaemia, hypomania, aggression, hostility, thinking abnormal, psychomotor hyperactivity, autonomic nervous system imbalance, dystonia, gastrointestinal disorder, hepatitis, hepatic function abnormal, jaundice, angioedema, photosensitivity reaction, urinary retention, oedema peripheral, and intraocular pressure increased. Less common adverse reactions were altered mood and intellectual impairment confusion.
In many of the spontaneous case reports of adverse behavioral effects, patients were receiving other CNS drugs concomitantly and/or were described as having underlying psychiatric conditions. Patients who have borderline personality disorder, a prior history of violent or aggressive behavior, or alcohol or substance abuse may be at risk for such events. Instances of irritability, hostility, and intrusive thoughts have been reported during discontinuance of Alprazolam in patients with post-traumatic stress disorder.
In addition, the following adverse events have been reported in association with the use of anxiolytic Benzodiazepines including Alprazolam, anorexia, fatigue, and slurred speech.
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