Voxatic Drug Interactions

Iron salt, antacids containing magnesium or aluminum: Levofloxacin has the potential to form stable co-ordinate compounds with some metals (Al, Cu, Zn, Mg, Ca). Antacids those are containing aluminum or magnesium and iron-containing drugs may reduce the absorption of levofloxacin. The administration of these drugs is recommended at least two hours before or after levofloxacin administration.
Sucralfate: Concomitant use with sucralfate may significantly reduce the bioavailability of levofloxacin. The administration of these drugs is recommended at least two hours after levofloxacin administration.
Theophylline, phenbufen, or NSAIDs: Pharmacokinetics interaction has not found between levofloxacin and theophylline. However, brain seizure threshold reduction may occur when quinolones is administered with theophylline, NSAIDs or other drugs that may reduce the seizure threshold.
The levels of levofloxacin will be approximately 13% higher in concomitant administration with phenbufen than its administration as a solo therapy.
Probenecid and cimetidine: Probenecid and cimetidine have statistically significant effects on levofloxacin elimination. The clearance of levofloxacin was reduced by cimetidine (24%) and probenecid (34%), because these drugs are able to hold levofloxacin secretion in renal tubular. Attention should be given when levofloxacin is used in conjunction with drugs that have a renal tubular secretory effect such as probenecid and cimetidine, especially in patients with renal function impairment.
Levofloxacin effect in other products: Cyclosporine: Concomitant use of levofloxacin and cyclosporine may elevate cyclosporine's half-time to 33%.
Vitamin K antagonists: Increased coagulation testing and/or bleeding has been reported in patients who treated with levofloxacin in combination with vitamin K antagonists (such as warfarin). Therefore, the coagulation tests need to be closely monitored in patients who also receive vitamin K antagonists therapy.
Drugs that known to cause QT interval prolongation.
Further attention is needed in levofloxacin administration to the patients who also received the drugs that known to cause QT interval prolongation (such as Class IA and III of anti-arrhythmia, anti-depressants tricyclic, macrolides, antipsychotic).
Interactions with food: There are no relevant interactions between levofloxacin and food.
The other relevant information: Levofloxacin is not affected to use concomitantly with: Calcium carbonate; Digoxin; Glibenclamide; Ranitidine.