Varivax Drug Interactions

Vaccination should be deferred for at least 5 months following blood or plasma transfusions, or administration of immune globulin or varicella zoster immune globulin (VZIG).
Following administration of VARIVAX (Refrigerated), any immune globulin including VZIG should not be given for 2 months thereafter unless its use outweighs the benefits of vaccination.
Vaccine recipients should avoid use of salicylates for 6 weeks after vaccination with VARIVAX (Refrigerated) as Reye syndrome has been reported following the use of salicylates during wild-type varicella infection.
Results from clinical studies indicate that VARIVAX (Refrigerated) can be administered concomitantly with M-M-R* II (Measles, Mumps, and Rubella Virus Vaccine Live), TETRAMUNE** (diphtheria and tetanus toxoids and pertussis vaccine adsorbed and Haemophilus b conjugate vaccine), or COMVAX* (Haemophilus influenzae type b conjugate and hepatitis B vaccine). If VARIVAX (Refrigerated) is not given concomitantly with M-M-R II, a 1-month interval between the 2 live virus vaccines should be observed.
Limited data from an experimental product containing varicella vaccine suggest that VARIVAX (Refrigerated) can be administered concomitantly with DTaP (diphtheria, tetanus, acellular pertussis) and PedvaxHIB* [Haemophilus b Conjugate Vaccine (Meningococcal Protein Conjugate)] using separate sites and syringes and with OPV (oral poliovirus vaccine).
Tuberculin skin testing, with tuberculin purified protein derivative (PPD), may be performed before VARIVAX is administered or on the same day, or at least 4 weeks following vaccination with VARIVAX, as other live virus vaccines may cause a temporary depression of tuberculin skin test sensitivity leading to false negative results.