Prevention of urothelial toxicity due to Oxazaphosphorines.
UROMESAN should always be given in tumour therapy with Ifosfamide. Where Cyclophosphamide is being used for tumour therapy, UROMESAN should always be given with bolus doses (over 10 mg/kg) of the cytotoxic agent and in all patients at special risk.
The principle risk factors are: Previous pelvic radiotherapy, cystitis with previous Ifosfamide, Cyclophosphamide therapy or a history of disorders of the urinary tract.