Uromesan Dosage/Direction for Use

Unless otherwise prescribed, UROMESAN is normally administered intravenously to adults at a dose of 20% of the Oxazaphosphorine dose at time zero (the time of administration of the Oxazaphosphorine), and then at 4 and 8 hours.
Example of UROMESAN administration with Oxazaphosphorine Injection: See Table 1.


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Clinical experience with children has shown that it is beneficial in individual cases to give UROMESAN at shorter intervals (e.g. every three hours, total UROMESAN dose = 60 % of Oxazaphosphorine dose). With very high-dose Oxazaphosphorine cytostatic therapy (e.g. before bone marrow transplantation), the total UROMESAN dose can be increased to between 120 and 160% of the Oxazaphosphorine dose. It is recommended that after administration of 20%, UROMESAN (related to the total dose of Oxazaphosphorine) at time zero the remaining calculated dose should be given continuously i.v. over a period of 24 hours with a perfusor. Alternatively an intermittent bolus injection is possible.
For adults 3 x 40% (at times 0, 4, 8 hours) or 4 x 40% (at times 0, 3, 6, 9 hours) respectively. For children due to more frequent micturition, the bolus injections should always be given in 3-hour intervals (e.g. 20% at time 0, 1, 3, 6, 9. 12 hours). Instead of a bolus injection, short infusions of 15 minutes duration are possible.
With continuous infusions of Ifosfamide, it has been shown to be of benefit to give UROMESAN at time zero following the initial 20% bolus injection (start of infusion, time 0), followed by infusion to up to 100% of the Ifosfamide dose, and to continue uroprotection for a further 6 to 12 hours after termination of the Ifosfamide infusion.
Example of UROMESAN administration with a 24-hours Ifosfamide infusion: See Table 2.


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