Uromesan Adverse Reactions

Isolated cases of partially organ-related hypersensitivity reactions (hyperergic reactions), e.g. skin and mucosal reactions of varying extent and severity (itching, redness, vesiculation), local tissue swelling (urticarial oedema), rare cases of drop in blood pressure and increased pulse rate above 100/min (tachycardia) due to severe acute hypersensitivity reactions (anaphylactoid reactions), and also a transient rise in certain liver function tests (transaminases) have been reported. There have been rare cases of venous irritation at the injection site.
In a tolerability study using high intravenous and oral doses of Mesna, single doses of 60 mg/kg body weight and above were associated with nausea-vomiting, diarrhoea, headache, joint pain, drop in blood pressure, tachycardia, skin reactions, exhaustion and weakness.
During treatment, the previously mentioned side-effects can not always be clearly differentiated from those caused by Oxazaphosphorines (Ifosfamide, Cyclophosphamide), or other concomitant medication.