Sanbelat Dosage/Direction for Use

Bleomycin is administered parenterally by intramuscular injection and intravenous injection/infusion in a dose of 5-15 U/m² once or twice a week. Application and dosage only with knowledge of the specialist literature. Dosage and intervals between injection vary dependin gon area and type of application, age and condition of the patient.
It is recommended to adjust the dose to the patient's body surface.
1. In squamous cell carcinomas: Intramuscular or intravenous injection of 10-15 U/m² once a week.
Intravenous infusion during 6-24 hours of 10-15 U/m² daily in 4 to 7 consecutive days every 3 to 4 weeks.
2. In Hodgkin's disease and non-Hodgkin lymphoma: Intramuscular or intravenous injection of 5-10 U/m² once a week.
Due to the risk of an anaphylactic reaction, the initial dose in lymphoma patients may be lower (2-3 U, for example).
If no acute reaction occurs, the normal dosage regimen can be applied.
3. In testis carcinomas: Intramuscular or intravenous injection of 10-15 U/m² once or twice a week.
Intravenous infusion during 6-24 hours of 10-15 U/m² daily in 5 to 6 consecutive days every 3 to 4 weeks.
The total dose of Bleomycin should not exceed 400 U (225 U/m² body surface), unless lung function examination justifies continuation of the administration. In elderly the dose is adjusted as follows: See table.


Click on icon to see table/diagram/image


Until more information is available, the administration of Bleomycin to children should only take place in special cases; adjustment of the dose preferably on the basis of the child's body surface.
In radiotherapy or if Bleomycin is used in combination therapies, increased toxicity can appear and the dose of bleomycin should be lowered.
Changes of the dose in impaired renal function as follows:
1. In serum creatinine of 177-354 micromol/L (2-4 mg%) the dose should be reduced by 50%.
2. In serum creatinine over 354 micromol/L (4 mg%) the dose should be reduced by more than 50%.
Intramuscular injection: The contents of the bottle of Bleomycin should be dissolved in 1-5 mL saline. Inject with the local anaesthetic, if necessary.
Repeated intramuscular injection at the same site may cause local reactions: it is therefore recommended to alter injection sites.
Intravenous injection: The contents of the bottle of Bleomycin should be dissolved in 5-10 mL saline and slowly injected during 5 -10 minutes.
Avoid a shorter injection time, as this will cause a high bleomycin concentration in the blood and will increase the risk of damage to the lungs when passing through.
Intravenous infusion: Bleomycin should be dissolved in 200-1000 mL saline.
The infusion can be administered as a short infusion for about 30 minutes or for a number of days.