Squamous cell carcinomas IM/IV inj 10-15 U/m
2 once a wk.
IV infusion During 6-24 hr of 10-15 U/m
2 daily in 4-7 consecutive days every 3-4 wk.
Hodgkin's disease & non-Hodgkin lymphoma 5-10 U/m
2 once a wk by IM/IV inj. Initial dose in lymphoma may be lowered to 2-3 U.
Testis carcinomas IM/IV inj 10-15 U/m
2 once or twice a wk.
IV infusion During 6-24 hr of 10-15 U/m
2 daily for 5-6 consecutive days every 3-4 wk. Max: 400 U.
Elderly ≥80 yr 15 U/wk. Total dosage: 100 U,
70-79 yr 30 U/wk. Total dosage: 150-200 U,
60-69 yr 30-60 U/wk. Total dosage: 200-300 U,
<60 yr 30-60 U/wk. Total dosage: 400 U.
Impaired renal function, serum creatinine >354 micromol/L Reduce dose by >50%,
serum creatinine 177-354 micromol/L Reduce dose by 50%.
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