Resfar Warnings

The possible presence of sulphurous odour dose not indicate an alternation of the products but is characteristic of the active ingredient contained in this preparation. The administration of NAC at high doses may reduce the prothrombin time. However, it is not established whether this is due to biological action of NAC or the result of an analytical interference. In any way the monitoring of coagulation factors is advisable particularly in case of liver transplantation. NAC may interfere with the determination of salycilates (colorimetric method) and with the determination of plasma and urinary ketones (nitroprusside test). Evaluation of experimental animal studies does not indicate teratogenic effects. The decision to use NAC at antidotal doses during pregnancy and lactation should be based on assessment of the risk-to-benefit ratio taking into consideration the particular characteristic of each case and in particular the risk for the mother and fetus induced by toxicant in the absence of specific treatment. In any case lactation must be suspended in case of poisoning.
Keep out the reach of children.