Renoguard Mechanism of Action

Pharmacology: Mechanism of Action: The mechanism of action of Ketoanalogue of essential amino acids is believed to involve in the prevention and therapy of damages due to faulty or deficient metabolism in chronic renal insufficiency. Ketoanalogues of essential amino acids allow the intake of essential amino acids while minimizing the amino-nitrogen intake.
Pharmacodynamics: Ketoanalogues of essential amino acids act to normalization of metabolic processes. Ketone bodies amino acids in total transamination to the L-amino acids, splitting with the urea. Nitrogen promotes recycling products exchange, anabolism proteins while reducing the urea concentration in serum. Ketoanalogues of essential amino acids also improve nitrogen exchange. It reduces ion concentrations of potassium, magnesium and phosphate.
Pharmacokinetics: The plasma kinetics of amino acids and their integration in metabolic pathways are well established. It should nevertheless be noted that in uremic patients, the plasma disturbances do not seem to depend on digestive amino acid intake, and that the post-absorptive kinetics seems to be disturbed very early in the development of the disease.