When Ketoanalogues of essential amino acids is used as one of the drugs in multiple regimens, the toxicity of Ketoanalogues of essential amino adds should be borne in mind in the selection and dosage of drugs with similar mechanism of actions. The addition of other drugs can necessitate changes and dose alterations.
Simultaneous administration of medicaments containing calcium may lead to pathological increase of serum calcium level or intensification. In order not to interfere with absorption, do not take drugs together with Ketoanalogues that come from sparingly soluble compounds with calcium (e.g. tetracycline).