Pharmacology: Vinorelbine Tartrate is a cytostatic antineoplastic of theVinca Alkaloids group. The molecular target of its activity is tubulin/microtubule dynamic equilibrium. Vinorelbine Tartrate inhibits the polymerization of tubulin. lt acts preferentially on mitotic microtubules and affects axonal microtubules only at high concentration. The effects on tubulin spiralization are lower than with Vincristine. Vinorelbine Tartrate blocks mitosis in phase G2+M and induces cell death at interphase or at the following mitosis.
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