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Acute pulmonary reaction have been reported with Vinorelbine Tartrate and other anticancer Vinca Alkaloids use in conjunction with Mitomycin. Although the pharmacokinetics of Vinorelbine Tartrate are not influenced by the concurrent administration of Cisplatin, the incidence of granulocytopenia with Vinorelbine Tartrate used in combination with Cisplatin is significantly higher than with single agent Vinorelbine Tartrate. Patients who receive Vinorelbine Tartrate and Paclitaxel, either concomitantly or sequentially, should be monitored for signs and symptoms of neuropathy. Administration of Vinorelbine Tartrate to patients with prior or concomitant radiation therapy may result in radiosensitizing effect.
Based on the available limited information, it is conceivable that interaction may occur with other drugs which are metabolised via the cytochrome CYP3A4. Concurrent administration of Vinorelbine with an inhibitor of this metabolic pathway may cause an earlier onset and/or increased severity of side effects.
