Relubin Caution For Usage

Instructions for Use/Handling: Handling guidelines: The preparation and administration of Vinorelbine Tartrate should be carried out by trained staff; suitable eye protection, disposable gloves, face mask and disposable apron should be worn. Eventual spillage or leakage should be mopped up.
As with other toxic compounds, caution should be exercised in handling and preparing the solution of VinorelbineTartrate. Skin reactions may occur with accidental exposure. The use of gloves is recommended. If the solution of Vinorelbine Tartrate contact the skin or mucosa, immediately wash the skin or mucosa thoroughly with soap and water. It is recommended to infuse Vinorelbine Tartrate over 6-10 minutes after dilution in 20-50 mL of normal saline or 5% Dextrose solution. After administration, the vein should be thoroughly flushed with at least 250 mL of isotonic solution.
Vinorelbine Tartrate must be given strictly intravenously: it is very important to make sure that the cannula is accurately placed in the vein before starting to infuse Vinorelbine Tartrate. If Vinorelbine Tartrate extravasates into the surrounding tissue during the administration, considerable local irritation may occur. In this case, the administration should be stopped, the vein flushed with normal saline and the remaining dose administered in another vein.
In case of extravasations, to reduce the risk of phlebitis, I.V glucocorticoids could be administered immediately.