Rativol Drug Interactions

Ketorolac is highly bound to human plasma protein, it will influence other drugs bound with plasma protein but not to influence plasma therapeutic from Digoxin, Warfarin, Ibuprofen, Naproxen, Acetaminophen, Phenytoin, Tolbutamide, or Piroxicam.
Although there is no significant interaction between Ketorolac and anticoagulant drug (i.e. Heparin, Warfarin), the administration of Ketorolac should be carefully and closely monitored.
Concomitantly use of Ketorolac Trometamol and Methotrexate should be used with caution since some prostaglandin synthesis inhibiting drugs have been reported to reduce the clearance of Methotrexate, and thus possibly enhance the toxicity of Methotrexate.
Concomitantly use of Ketorolac Trometamol with ACE inhibitor and other NSAIDs might raise the risk of renal disorder, especially in dehydrated patients.
Ketorolac Trometamol reduces the diuretic response to Furosemide in normovolaemic healthy subjects by approximately 20%.
Sporadic cases of seizures have been reported during concomitant use of Ketorolac and antiepileptic drugs (Phenytoin, Carbamazepine).
Hallucination has been reported when Ketorolac Trometamol was used in patients taking psychoactive drugs.
Concomitantly use of Ketorolac Trometamol with Acetosal or other NSAIDs might worsen the adverse reactions.
Concomitantly use of Ketorolac Trometamol with Lithium and Methotrexate will prolong Lithium and Methotrexate clearance through kidney.
Concomitantly use of Ketorolac Trometamol with probenecid will reduce Ketorolac elimination in kidney that will increase Ketorolac assay.
Ketorolac ampoules are compatible with normal saline, 5% dextrose, Ringer's solution, Ringer lactate solution, or Plasmalyte solution.