A history of active peptic ulceration or gastrointestinal bleeding.
Suspected or confirmed cerebrovascular bleeding.
Haemorrhagic diatheses including coagulation disorders.
Hypersensitivity to Ketorolac Trometamol or other NSAIDs and those patients in whom Acetosal or other prostaglandin synthesis inhibitors induce allergic reactions.
The complete or partial syndrome of nasal polyps, angioedema or bronchospasm.
Concurrent treatment with other NSAIDs, Oxpentifylline, Probenecid or Lithium salts.
Hypovolaemia from any cause or dehydration.
A history of asthma.
Patients who have had operations with a high risk of haemorrhage or incomplete haemostasis.
Patients on anticoagulants including low dose heparin (2500-5000 units twelve hourly).
During pregnancy, labour, delivery or lactation.
Children under 16 years of age.
Ketorolac Trometamol is contraindicated in patients currently receiving Acetosal.
Moderate or severe renal impairment (serum creatinine > 160 μmol/L).
Neuraxial (epidural or intrathecal) administration.
Prophylactic administration before major surgery or intraoperatively when haemostasis is critical because of the increased risk of bleeding.