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Pharmacology: Mode of Action: Praxilene has been shown to exert a direct effect on intracellular metabolism. Thus, it has been demonstrated in men and animals that it produces an increase of ATP levels, and a decrease of lactic acid levels in ischemic conditions, evidence for an enhancement of cellular oxidative capacity. Furthermore, Praxilene is a powerful spasmolytic agent.
Peripheral Vascular Disorders: Painful symptoms of arteritis, intermittent claudication, night cramps, rest pain, incipient gangrene, trophic ulcers, Raynaud's syndrome, diabetic arteriopathy and acrocyanosis.
Cerebral Vascular Disorders: Cerebral insufficiency and cerebral atherosclerosis, particularly where these manifest themselves as mental deterioration and confusion in the elderly.
Sugar-Coated Tab: Adults and the Elderly: Peripheral Vascular Disorders: 1-2 tab 3 times daily.
Cerebral Vascular Disorders: 1 tab 3 times daily.
Film-Coated Tab: 1 tab 3 times.
Treatment Duration: Minimum of 3 months.
Children: There is no recommended dose.
Symptoms: Depression of cardiac conduction and convulsions may occur.
Treatment: When this occurs, gastric lavage should be employed. Following overdosage, there may be depression of cardiac conduction and in severe cases, treatment with isoprenaline injection or electrical pacemaking should be considered. Convulsive crises may also be observed and these may be managed by diazepam.
Hypersensitivity to naftidrofuryl oxalate or to any of the components of Praxilene. Certain disorders of cardiac function and atrioventricular block.
Caution should be exercised in patients with severe cardiac insufficiency, conduction disorders and renal or hepatic insufficiency. The possibility of an additive effect occurring between Praxilene, and antiarrhythmic and β-adrenergic-blocking drugs should be considered.
Use in pregnancy & lactation: There is no or inadequate, evidence of safety of Praxilene in human pregnancy, but it has been used for many years without apparent ill consequence, animal studies have shown no hazard. If drug therapy is needed in pregnancy, Praxilene can be used if there is no safer alternative. There is no information available regarding Praxilene's use during lactation.
There is no or inadequate, evidence of safety of Praxilene in human pregnancy, but it has been used for many years without apparent ill consequence, animal studies have shown no hazard. If drug therapy is needed in pregnancy, Praxilene can be used if there is no safer alternative. There is no information available regarding Praxilene's use during lactation.
Praxilene is normally well tolerated in the dosage recommended. Occasionally, nausea, epigastric pain or skin reactions have been noted. In case of disorders of cardiac rhythm, neurological disorders, inform the physician immediately.
Store at temperature below 25°C.
C04AX21 - naftidrofuryl ; Belongs to the class of other peripheral vasodilators.
Praxilene FC tab 200 mg
10 × 10's (Rp953,400/boks)
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