Peinlos Use In Pregnancy & Lactation

Pregnancy: Ibuprofen is contraindicated for use during the third trimester of pregnancy because of risk of premature closure of the ductus arteriosus and the potential to prolong parturition.
There are no adequate, well-controlled studies in pregnant women. Prior to the third trimester of pregnancy, should be used only if the potential benefit to the mother justifies the potential risk to the fetus.
Inhibition of prostaglandin synthesis may adversely affect pregnancy and/or the embryofetal development. Data from epidemiological studies suggest an increased risk of miscarriage and of cardiac malformation after use of a prostaglandin synthesis inhibitor in early pregnancy.
Labor and Delivery: The effects of Ibuprofen on labor and delivery in pregnant women are unknown. In rat studies, maternal exposure to NSAIDs, as with other drugs known to inhibit prostaglandin synthesis, increased the incidence of dystocia and delayed parturition, and decreased pup survival.
Nursing Mothers: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Ibuprofen, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.