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Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be at least 30 minutes. The highest recommended dose is 2400 mg daily. Do not exceed 3200 mg. Similarly, going beyond 24 hours must be justified based on benefits over risks assessments.
Preparation and Administration: Concentrated injection must be diluted prior to intravenous (IV) infusion.
Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride (normal saline) or 5% Glucose.
400 mg dose: Dilute 4 mL of Injection in no less than 100 mL of diluent.
800 mg dose: Dilute 8 mL of Injection in no less than 200 mL of diluent.
Visually inspect Injection for particulate matter and discolouration prior to administration, whenever solution and container permit. If visibly opaque particles, discolouration or other foreign particulates are observed, the solution should not be used. Once diluted the solution should be used as soon as possible. It is a sterile solution for single use and contains no antimicrobial preservative.
Infusion time is 30 minutes.
Injection should be used in one patients on one occasion only. It contains no antimicrobial preservative. Unused solution should be discarded.
