May increase risk of serious CV thrombotic events, MI, stroke; serious GI adverse events including bleeding, ulceration & perforation of the stomach or intestines. Concurrent use w/ aspirin, oral corticosteroids, anticoagulants, ACE inhibitors, thiazides or loop diuretics. Smoking or alcohol use. Poor general health status. Prior history of ulcer disease or GI bleeding. Evaluate for evidence of development of severe hepatic reaction in patients w/ symptoms &/or signs suggesting liver dysfunction or w/ abnormal liver test values. Discontinue if clinical signs & symptoms consistent w/ liver disease develop; at 1st appearance of skin rashor any other sign of hypersensitivity. HTN. Monitor BP closely during initiation & throughout the therapy. Fluid retention or heart failure. Considerable dehydration. Masking inflammation & fever. Check Hb or hematocrit if patient exhibit any signs or symptoms of anemia or blood loss. Coagulation disorders. Patients w/ pre-existing asthma. Blurred or diminished vision, scotomata & changes in color vision. Aseptic meningitis. Periodically check CBC & chemistry profiles. Impaired renal or hepatic function. Avoid during pregnancy. Lactation. Childn <18 yr. Elderly.
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