Prevention of post-op nausea &/or vomiting Initially 8 mg given 1 hr before anaesth, followed by 8 mg every 8 hr for up to 16 hr. Nausea & vomiting of radiotherapy 8 mg every 8 hr commencing 1-2 hr prior to the first fraction of radiotherapy. The course of the therapy depend on the duration of radiotherapy. Patient w/ hepatic impairment Max total daily dose: 8 mg.