Each mL contains: Ondansetron Hydrochloride Dihydrate equivalent to Ondansetron 2 mg.
Pharmacology: Ondansetron is a selective 5-HT3 receptor antagonist and competitively prevent or treat nausea and vomiting associated with cytotoxic chemotherapy and radiotherapy.
ONDACAP injection is indicated for the management of nausea and vomiting induced by chemotherapy, radiotherapy, and operation.
Treatment of Postoperative Nausea and Vomiting: ONDACAP Injection 4 mg as single dose by i.m. or slow i.v. injection.
Prevention of Nausea and Vomiting Associated with Chemotherapy and Radiotherapy: Adult: Highly emetogenic chemotherapy, such as Cisplatin. Initially administer ONDACAP Injection 8 mg i.v. slowly or given as infusion for 15 minutes immediately before the start of chemotherapy, followed by continuous infusion of Ondansetron 1 mg/hour for less than 24 hours or 2 of ONDACAP Injection 8 mg administered by i.v. slowly or as infusion for 15 minutes with time interval 4 hours. Also could be followed by 8 mg orally twice daily for less than 5 days.
Moderately Emetogenic Chemotherapy, such as Cyclosphamide. ONDACAP Injection 8 mg administered i.v. slowly or as infusion for 15 minutes immediately before the start of chemotherapy, followed by 8 mg orally twice daily for less than 5 days.
Children older than 4 years: 5 mg/m2 by i.v. over 15 minutes immediately prior to chemotherapy, followed by 4 mg orally every 12 Hours for up to 5 days.
Geriatric: ONDACAP is well tolerated by patients > 65 years and no need alterations of daily dose, frequency or route of administration.
Patient with Impaired Renal Function: No need alterations of daily dose, frequency or route of administration.
Patient with Impaired Hepatic Function: Total daily dose of 8 mg should not be exceeded.
There is no specific antidote.
Hypersensitivity to Ondansentron.
It should not be used during pregnancy, particularly in the 1st semester, unless the potential benefit outweighs the potential risk.
Lactating mothers were suggested not to breastfeed.
Headache, a sensation of flushing or warmth in the head and epigastrum, sedation, constipation and diarrhea.
Store below 30°C, away from light.
A04AA01 - ondansetron ; Belongs to the class of serotonin (5HT3) antagonists. Used for the prevention of nausea and vomiting.
Ondacap inj 2 mg/mL
2 mL x 5 × 1's (Rp132,000/boks);4 mL x 5 × 1's (Rp210,500/boks)
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